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La Jolla Pharmaceutical Company
La Jolla Pharmaceutical Company
(LJPC)
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Drug Name
Phase 1
Phase 2
Phase 3
Phase 4
Indication
Angiotensin ii
healthy volunteers/patients
,
hypertrophic cardiomyopathy
,
cardiomyopathies
,
headache
,
cluster headache
,
diabetic retinopathy
,
breast neoplasms
,
hyperkalemia
,
migraine disorders
,
migraine without aura
,
migraine with aura
,
aortic valve stenosis
,
pathologic constriction
,
cardiotoxicity
,
retinal diseases
,
proteinuria
,
atrial fibrillation
,
stroke
,
chronic renal insufficiency
,
renal insufficiency
,
hypertension
,
heart failure
,
type 2 diabetes mellitus
,
diabetes mellitus
,
type 1 diabetes mellitus
,
hypertrophy
,
obesity
,
kidney diseases
,
left ventricular dysfunction
,
ventricular dysfunction
,
left ventricular hypertrophy
,
glucose intolerance
,
cohort studies
,
essential hypertension
,
diabetic nephropathies
Calcium dobesilate
breast neoplasms
,
malignant mesothelioma
,
mesothelioma
,
plasma cell neoplasms
,
precursor cell lymphoblastic leukemia-lymphoma
,
lymphoid leukemia
,
lymphoma
,
non-hodgkin lymphoma
,
precursor t-cell lymphoblastic leukemia-lymphoma
,
t-cell leukemia
,
b-cell leukemia
,
arthritis
,
gouty arthritis
,
prostatic neoplasms
,
mantle-cell lymphoma
,
multiple myeloma
,
leukemia
,
macular edema
,
edema
,
vision disorders
,
low vision
,
myeloid leukemia acute
,
myeloid leukemia
,
retinal vein occlusion
Serine
invasive candidiasis
,
candidiasis
,
aspergillosis
,
invasive pulmonary aspergillosis
Sodium chloride
healthy volunteers/patients
,
neoplasms
,
heart failure
,
colorectal neoplasms
,
chronic renal insufficiency
,
kidney diseases
,
cystic fibrosis
,
cholangiocarcinoma
,
biliary tract neoplasms
,
gallbladder neoplasms
,
drug-related side effects and adverse reactions
,
renal insufficiency
,
cardiovascular diseases
,
type 2 diabetes mellitus
,
major depressive disorder
,
depressive disorder
,
diabetes mellitus
,
non-small-cell lung carcinoma
,
depression
,
chronic obstructive pulmonary disease
,
obstructive lung diseases
,
sepsis
,
septic shock
,
shock
,
toxemia
,
treatment-resistant depressive disorder
,
lung diseases
,
hidradenitis suppurativa
,
hidradenitis
,
small cell carcinoma
,
obesity
,
fibrosis
,
non-alcoholic fatty liver disease
,
fatty liver
,
hypersensitivity
,
syndrome
,
drug hypersensitivity syndrome
,
carcinoma
,
lung neoplasms
,
hepatocellular carcinoma
,
liver neoplasms
,
small cell lung carcinoma
,
sars-cov-2
,
respiratory tract infections
,
asthma
,
vasculitis
,
churg-strauss syndrome
,
recurrence
,
ovarian neoplasms
,
ovarian epithelial carcinoma
,
gastroesophageal reflux
,
peptic esophagitis
,
esophagitis
,
infections
,
respiratory syncytial virus infections
,
coronavirus infections
,
coronavirus
,
hematologic diseases
,
hypereosinophilic syndrome
,
eosinophilia
,
leukocyte disorders
,
uterine cervical neoplasms
,
covid-19
,
hypertension
,
breast neoplasms
,
postoperative pain
Aldosterone
acute coronary syndrome
,
syndrome
,
heart failure
,
systolic heart failure
,
systolic murmurs
Aspartame
tuberculosis
,
neoplasms
,
leukemia
,
myeloid leukemia acute
,
myeloid leukemia
,
deficiency diseases
,
paraproteinemias
,
hiv infections
,
precursor cell lymphoblastic leukemia-lymphoma
,
lymphoid leukemia
,
breast neoplasms
,
immune system diseases
,
hematologic neoplasms
,
type 2 diabetes mellitus
,
uveitis
,
metabolic diseases
,
disease
,
lipidoses
,
immunoglobulin g4-related disease
,
malaria
,
falciparum malaria
,
whooping cough
,
tetanus
,
diphtheria
,
tetany
,
polycystic kidney diseases
,
autosomal dominant polycystic kidney
,
arthrogryposis
,
renal insufficiency
,
hematologic diseases
,
blood protein disorders
,
neoplasms by histologic type
,
prostatic neoplasms
,
circulating neoplastic cells
,
heart transplantation
,
non-small-cell lung carcinoma
,
lung neoplasms
,
carcinoma
,
nasopharyngeal carcinoma
,
nasopharyngeal neoplasms
,
esophageal neoplasms
,
adenocarcinoma
,
neoplasm metastasis
,
anemia
,
aplastic anemia
,
multiple myeloma
,
plasma cell neoplasms
,
hypercholesterolemia
,
hyperlipoproteinemia type ii
,
meningococcal infections
,
hemolytic anemia autoimmune
,
meningitis
,
meningococcal meningitis
,
stomach neoplasms
,
hemophilia a
,
kidney diseases
,
gaucher disease
,
smoldering multiple myeloma
,
hemophilia b
,
chronic renal insufficiency
,
hyperphosphatemia
,
multiple sclerosis
,
sclerosis
,
homozygous familial hypercholesterolemia
,
pharyngitis
,
tonsillitis
,
healthy volunteers/patients
,
asthma
,
glycogen storage disease type ii
,
glycogen storage disease
,
atopic dermatitis
,
dermatitis
,
lymphoma
,
eczema
,
diabetes mellitus
,
hyperglycemia
,
glycogen storage disease type iii
,
non-hodgkin lymphoma
,
osteoporosis
,
postmenopausal osteoporosis
,
lymphoproliferative disorders
Bevifimod
healthy volunteers/patients
,
hepatic insufficiency
,
ovarian epithelial carcinoma
,
castration-resistant prostatic neoplasms
,
myeloid leukemia acute
,
myeloid leukemia
,
liver failure
,
uveal neoplasms
,
uveal melanoma
,
liver diseases
,
huntington disease
,
squamous cell carcinoma of head and neck
,
squamous cell carcinoma
,
hiv seropositivity
,
sarcoma
,
central nervous system neoplasms
,
mantle-cell lymphoma
,
non-hodgkin lymphoma
,
uterine cervical neoplasms
,
plasma cell neoplasms
,
salivary gland neoplasms
,
cholangiocarcinoma
,
neuroendocrine tumors
,
hepatitis b
,
chronic hepatitis b
,
hepatitis
,
hepatitis a
,
unknown primary neoplasms
,
lobular carcinoma
,
invasive hydatidiform mole
,
ischemia
,
coronary artery disease
,
myocardial ischemia
,
gastrointestinal neoplasms
,
respiratory tract diseases
,
digestive system neoplasms
,
gastrointestinal diseases
,
respiratory tract neoplasms
,
bronchogenic carcinoma
,
thoracic neoplasms
,
intestinal neoplasms
,
digestive system diseases
,
colonic diseases
,
intestinal diseases
,
bronchial neoplasms
,
waldenstrom macroglobulinemia
,
follicular lymphoma
,
myelodysplastic syndromes
,
preleukemia
,
syndrome
,
exanthema
,
uterine neoplasms
,
female genital neoplasms
,
bronchiolo-alveolar adenocarcinoma
,
glioblastoma
,
nasopharyngeal carcinoma
,
nasopharyngeal neoplasms
,
neoplasms
,
breast neoplasms
,
carcinoma
,
colorectal neoplasms
,
triple negative breast neoplasms
,
lymphoma
,
hepatocellular carcinoma
,
liver neoplasms
,
renal cell carcinoma
,
leukemia
,
ovarian neoplasms
,
neoplasm metastasis
,
brain neoplasms
,
b-cell chronic lymphocytic leukemia
,
head and neck neoplasms
,
lymphoid leukemia
,
hematologic neoplasms
,
prostatic neoplasms
,
multiple myeloma
,
thyroid neoplasms
,
papillary thyroid cancer
,
large-cell lymphoma anaplastic
,
neoplasms by site
,
glioma
,
thyroid diseases
,
lymphoproliferative disorders
,
neoplasms by histologic type
,
malignant mesothelioma
,
mesothelioma
,
neuroblastoma
,
anaplastic thyroid carcinoma
,
laryngeal neoplasms
,
erdheim-chester disease
,
mucinous adenocarcinoma
,
ductal carcinoma breast
,
inflammatory breast neoplasms
,
kidney transplantation
,
bcr-abl positive chronic myelogenous leukemia
,
non-small-cell lung carcinoma
,
lung neoplasms
,
melanoma
,
hiv infections
,
pancreatic neoplasms
,
infections
,
communicable diseases
,
adenocarcinoma
,
acquired immunodeficiency syndrome
,
disease progression
,
adenocarcinoma of lung
,
kidney diseases
,
polyomavirus infections
,
liver cirrhosis
,
cardiotoxicity
,
fibrosis
,
hemorrhage
,
endometrial neoplasms
,
uterine hemorrhage
,
postmenopause
,
hiv-1
,
alzheimer disease
,
frontotemporal dementia
,
progressive supranuclear palsy
,
primary progressive aphasia
,
pick disease of the brain
,
hodgkin disease
,
large b-cell lymphoma diffuse
,
b-cell lymphoma
Hepcidin
anemia
,
iron-deficiency anemia
,
iron deficiencies
,
neoplasm metastasis
,
inflammatory bowel diseases
,
deficiency diseases
Microcrystalline cellulose
carcinoma
,
ovarian neoplasms
,
serous cystadenocarcinoma
,
fallopian tube neoplasms
,
carcinosarcoma
,
hereditary breast and ovarian cancer syndrome
,
mullerian mixed tumor
,
recurrence
,
leukemia
,
myeloid leukemia acute
,
precursor cell lymphoblastic leukemia-lymphoma
,
myeloid leukemia
,
precursor t-cell lymphoblastic leukemia-lymphoma
,
acute disease
,
lymphoid leukemia
Vp16
urologic neoplasms
,
urinary bladder neoplasms
,
urethral neoplasms
,
transitional cell carcinoma
,
neuroendocrine tumors
,
neuroblastoma
,
bone neoplasms
,
kidney neoplasms
,
lymphoma
,
hodgkin disease
,
osteosarcoma
,
carcinoma
,
prostatic neoplasms
,
castration-resistant prostatic neoplasms
,
small cell carcinoma
,
neuroendocrine carcinoma
,
large b-cell lymphoma diffuse
,
sarcoma
,
non-hodgkin lymphoma
,
b-cell lymphoma
,
glioma
,
central nervous system neoplasms
,
nervous system neoplasms
,
recurrence
,
sclerosis
,
thyroid neoplasms
,
ovarian neoplasms
,
ovarian epithelial carcinoma
,
ewing sarcoma
,
primitive neuroectodermal tumors
,
primitive neuroectodermal tumors peripheral
,
neuroectodermal tumors
,
small cell lung carcinoma
,
lung neoplasms
,
non-small-cell lung carcinoma
,
neoplasms
,
vomiting
,
nausea
Catecholamines
healthy volunteers/patients
,
endocrine system diseases
,
exercise
,
psychotic disorders
,
pheochromocytoma
,
myocardial infarction
,
hyperkinesis
,
schizophrenia
,
neuroendocrine tumors
,
paraganglioma
,
infarction
,
inferior wall myocardial infarction
,
narcolepsy
,
neuroendocrine carcinoma
,
sleep initiation and maintenance disorders
,
craniocerebral trauma
,
nervous system trauma
,
drug-related side effects and adverse reactions
,
temporomandibular joint disorders
,
temporomandibular joint dysfunction syndrome
,
traumatic stress disorders
,
traumatic stress disorders acute
,
autonomic nervous system diseases
,
hypotension
,
nervous system diseases
,
primary dysautonomias
,
obesity
,
syndrome
,
orthostatic intolerance
,
postural orthostatic tachycardia syndrome
,
anorexia
,
orthostatic hypotension
,
cardiac surgical procedures
,
respiratory distress syndrome
,
bronchiolitis
,
weight loss
,
fluid therapy
,
infections
,
low cardiac output
,
cachexia
,
acute lung injury
,
newborn respiratory distress syndrome
,
carotid stenosis
,
neonatal sepsis
,
shock
,
septic shock
,
hypertension
,
wounds and injuries
,
sepsis
,
diabetes mellitus
,
hypoglycemia
,
traumatic brain injuries
,
brain injuries
,
heart failure
,
type 1 diabetes mellitus
,
tachycardia
,
critical illness
,
cardiogenic shock
,
type 2 diabetes mellitus
,
cardiac arrhythmias
,
covid-19
,
coronavirus infections
,
respiratory tract diseases
,
respiration disorders
,
endotoxemia
,
parkinson disease
,
psychological stress
,
acute kidney injury
,
pure autonomic failure
,
inflammation
,
depressive disorder
,
respiratory insufficiency
,
cardiovascular diseases
,
takotsubo cardiomyopathy
,
essential hypertension
,
depression
,
attention deficit disorder with hyperactivity
,
heart arrest
,
cardiomyopathies
,
hemorrhage
,
ischemic stroke
,
subarachnoid hemorrhage
,
stroke
,
adrenal gland neoplasms
,
adrenocortical carcinoma
,
anorexia nervosa
,
hyperaldosteronism
,
chronic kidney failure
,
bradycardia
,
shy-drager syndrome
,
multiple system atrophy
,
atrophy
,
autoimmune diseases
,
major depressive disorder
,
bulimia
,
feeding and eating disorders
,
bulimia nervosa
,
reward
,
kidney diseases
,
heart diseases
,
metabolic syndrome
,
neuralgia
,
restless legs syndrome
,
psychomotor agitation
,
physiological stress
,
burns
,
intraoperative complications
,
high cardiac output
,
respiratory aspiration of gastric contents
,
multiple organ failure
,
hyperemia
,
adrenal insufficiency
,
prostatic neoplasms
,
chronic obstructive pulmonary disease
,
treatment outcome
,
cytokine release syndrome
,
toxemia
,
mammaplasty
,
free tissue flaps
,
microsurgery
,
glaucoma
,
raynaud disease
,
hand-arm vibration syndrome
,
postoperative pain
,
postoperative complications
,
ultrasonic therapy
,
vitiligo
,
hematoma
,
pulmonary embolism
,
embolism
,
obstructive sleep apnea
,
sleep apnea syndromes
,
apnea
,
menopause
,
sudden death cardiac
,
death
,
food intolerance
,
enteral nutrition
,
vasovagal syncope
,
syncope
,
post-traumatic stress disorders
,
abdominal obesity
,
adrenocortical adenoma
,
delirium
,
melanoma
,
acute coronary syndrome
,
pancreatitis
,
phenylketonurias
,
aphthous stomatitis
,
stomatitis
,
thyroid diseases
,
neuroblastoma
,
precancerous conditions
,
hyperplasia
,
congenital adrenal hyperplasia
,
adrenogenital syndrome
,
adrenocortical hyperfunction
,
open-angle glaucoma
,
hypersensitivity
,
laparoscopic cholecystectomy
,
lung injury
,
heart disease risk factors
,
sleep
,
circadian rhythm
,
knee osteoarthritis
,
osteoarthritis
,
fasting
,
cold temperature
,
myofascial pain syndromes
,
fibromyalgia
,
renal insufficiency
,
hypoxia
,
altitude sickness
,
resistance training
,
blood flow restriction therapy
,
pituitary acth hypersecretion
,
cushing syndrome
,
adrenal rest tumor
,
adrenal gland diseases
,
neoplasm metastasis
,
spinal cord injuries
,
pulmonary heart disease
,
extracorporeal membrane oxygenation
,
hypothermia
,
out-of-hospital cardiac arrest
,
post-cardiac arrest syndrome
,
temperature
,
overweight
,
high-intensity interval training
Mydfrin
healthy volunteers/patients
,
pharmacokinetics
,
biological availability
,
type 1 diabetes mellitus
,
type 2 diabetes mellitus
,
diabetes mellitus
,
hyperglycemia
,
cardiovascular diseases
,
drug-related side effects and adverse reactions
,
alzheimer disease
,
chronic obstructive pulmonary disease
,
lung diseases
,
obstructive lung diseases
,
heart failure
,
therapeutic equivalency
,
hypertriglyceridemia
,
gastroesophageal reflux
,
peptic esophagitis
,
asthma
,
barrett esophagus
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